DATE:

Friday, November 5, 2021

TIME:

3:30 PM

LOCATION:

GMCS 314

SPEAKER:

Parag Katira, Mechanical Engineering, San Diego State University

ABSTRACT:

Adsorption of proteins is a critical first step that determines the response of a biological system to a newly introduced material surface. Being able to predict and control protein adsorption is then an important goal in surface engineering for a variety of biomedical applications and bioengineering applications. Here, using simple computational models, we try to understand the factors that govern adsorption of proteins to surfaces. We focus on two key experimental observations – 1) the amount of time proteins spend on an adsorptive surface, and 2) the adsorption preventive behavior of surfaces coated with hydrophilic polymers. Many models of varying complexity have been developed over the last few decades to explain protein-surface interactions and protein adsorption, however, we find that most of the experimentally observed phenomena can be captured by simple analytical or computational models. In this talk, I will present these data and the models and discuss their implications as well as shortcomings.

HOST:

Jose Castillo

VIDEO: