DATE:

Friday, September 11, 2020

TIME:

3:00 PM

LOCATION:

Virtual Zoom Conference

SPEAKER:

Dr. Uduak George, Mathematics and Statistics, San Diego State University

ABSTRACT:

Lung development is a highly stereotyped process that is regulated by molecular factors. Ligands such as fibroblast growth factor 10 (Fgf10) play critical roles in lung development. Fgf10 controls the development of the branching epithelial structures that form the future airways. Mice that do not express Fgf10 exhibit severe lung abnormalities. The pattern of Fgf10 expression increases in complexity during development. Disruption of the spatiotemporal expression of Fgf10 causes lung abnormalities. Understanding the temporal and spatial regulation of Fgf10 expression is challenging because of the complex nature of lung development. Mathematical modeling is a powerful tool for unraveling the dynamics of Fgf10 expression. In this talk, I will present the new mathematical models we have developed to study Fgf10 expression pattern. I will also present new findings from the model simulations that for the first time identifies lung size as a regulator of the complexity of Fgf10 patterning.

HOST:

Jose Castillo

VIDEO: