TITLE:

Feedback, lineages and cancer

DATE:

Friday, April 19th, 2013

TIME:

3:30 PM

LOCATION:

GMCS 214

SPEAKER:

John Lowengrub.
Chancellor’s Professor of Mathematics, Biomedical Engineering, Chemical Engineering and Materials Science.
University of California, Irvine.

ABSTRACT:

Most tissues are hierarchically organized into lineages, which are sets of
progenitor-progeny relationships where the cells differ progressively in
their character due to differentiation. It is increasingly recognized that
lineage progression occurs in solid tumors. In this talk, we develop a
multispecies continuum model to simulate the dynamics of cell lineages in
solid tumors. The model accounts for spatiotemporally varying cell
proliferation and death mediated by the heterogeneous distribution of
oxygen and soluble chemical factors. Together, these regulate the rates of
self-renewal and differentiation of the different cells within the
lineages and lead to the development of heterogenous cell distributions
and formation of niche-like environments for stem cells. As demonstrated
in the talk, the feedback processes are found to play a critical role in
tumor progression, the development of morphological instability, and
response to treatment.

HOST:

Dr. Jose Castillo.

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