TITLE:

Encoding the Heart: Extending Our Understanding of Heart Disease through Computational Biology

DATE:

Friday, December 7th, 2007

TIME:

3:30 PM

LOCATION:

GMCS 214

SPEAKER:

Roberta Gottlieb, Director of the Bioscience Center, San Diego State University

ABSTRACT:

I will present three applications of computational sciences to the study of heart disease. I have no expertise in the computational side but will focus on the biological systems in order to invite dialog on the approaches to their quantitative study.

1) Fluorescence microscopy is used to understand cell biological processes of mitochondrial fusion and fission events as well as autophagy in cells and heart tissues: we need to develop rapid optical image analysis algorithms

2) Proteomics and the explosion of information from the human genome project has expanded our ability to mine databases for new insights: we plan to study the proteome of cardiac autophagosomes in health and disease

3) Bioinformatics tools allow us to draw correlations from seemingly disparate observations: how we plan to apply this in the study of periodontal disease and atherosclerosis

HOST:

Paul Paolini

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