TITLE:

Absolute Robustness in Deterministic and Stochastic Chemical Reaction Networks

DATE:

Friday, February 20th, 2015

TIME:

3:30 PM

LOCATION:

GMCS 214

SPEAKER:

Dr. German Enciso. Dept. Of Mathematics at University of California Irvine

ABSTRACT:

Chemical reaction networks lie at the heart of many biological processes at the cell level. These processes are often under strict regulation to prevent an unintended outcome in the face of noise. An important scientific problem is to discover the mechanisms used by cells to produce a consistent phenotype despite protein variability.

In this talk, I will discuss structural conditions on chemical reaction networks that guarantee absolute robustness with respect to some protein concentrations but not others. Such structural conditions hold under arbitrary parameter values. I will discuss deterministic as well as stochastic aspects of this robustness. As an application, I discuss an ultrasensitive input/output network that is robust to non-input proteins.

HOST:

Dr. Jose Castillo

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