TITLE:

A SIMPLE MODEL FOR THE MUCUS DISTRIBUTION IN A LUNG WITH CYSTIC FIBROSIS

DATE:

Friday, Dec 9th, 2011

TIME:

3:30 PM

LOCATION:

GMCS 214

SPEAKER:

Sara Zarei.
Computational Science Research Center.
San Diego State University.

ABSTRACT:

Cystic fibrosis (CF) is the most common autosomal recessive
disease in Caucasians associated with early mortality with a reported
incidence of 1 in 3200 live births. Host inflammatory responses result in
airway mucus plugging, airway wall edema and eventual destruction of
airway wall support structure. Despite very aggressive treatment, the
median age of survival is approximately 38 years. This work is the first
attempt to quantitatively characterize the distribution of mucus in a CF
lung as a function of time. The model perforce makes arbitrary choices and
at each stage of the model construction, the simplest choice is made. The
model is complicated enough to fit the average CF patients’ spirometric
data over time and to identify several interesting parameters. More
complicated versions of the model appropriate for describing single
patient MRI data are discussed.

HOST:

Dr. Jose Castillo.

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