Machine Learning Mediated Discovery of Genetic Modifiers of Huntington’s Disease
TITLE:
Machine Learning Mediated Discovery of Genetic Modifiers of Huntington’s Disease
DATE:
Friday, June 26, 2020
TIME:
3:00 PM
LOCATION:
Virtual Zoom Conference
SPEAKER:
Dr. Animesh Ray, Computational and Molecular Biology, Keck Graduate Institute
ABSTRACT:
Huntington’s disease is a genetic disorder in which a stretch of repeated triplet nucleotides, 5’-(CAG)n-3’, is expanded (relative to those in unaffected people) within a protein-coding gene, known as the ‘Huntingtin’ gene or HTT. While the fundamental genetic basis is clear, the disease is highly complex and the disease severity and the age of onset depend on a number of other factors, both genetic and environmental. Moreover, the molecular basis of the disease is highly complex and is still controversial. I will describe our machine learning approaches combined with focused model organism studies, which appear to implicate DNA repair as an important factor in this disease.
HOST:
Jose Castillo
VIDEO: