DATE:

Friday, October 4, 2019

TIME:

3:30 PM

LOCATION:

GMCS-314

SPEAKER:

Dominik Wodarz, Ph.D,Professor of Theoretical/Mathematical Biology, Department of Ecology and Evolutionary Biology, University of California, Irvine.

ABSTRACT:

The talk will discuss the use of mathematical models for understanding targeted cancer therapies.
One area of focus is the treatment of chronic lymphocytic leukemia with tyrosine kinase inhibitors.
I will explore how mathematical approaches have helped elucidate the mechanism of action of the
targeted drug ibrutinib, and will discuss how evolutionary models, based on patient-specific parameters,
can make individualized predictions about treatment outcomes. Another focus of the talk is the use of
oncolytic viruses to kill cancer cells and drive cancers into remission. These are viruses that
specifically infect cancer cells and spread throughout tumors. I will discuss mathematical models
applied to experimental data that analyze virus spread in a spatially structured setting, concentrating
on the interactions of the virus with innate immune mechanisms that determine the outcome of virus spread.

HOST:

Naveen Vaidya, Department of Mathematics and Statistics

DOWNLOAD:

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