In a pattern of increasing global spread since the 1960's, dengue threatens 40 f the world's population annually. In endemic areas such as southeast Asia, hemorrhagic fever, the severe and sometimes fatal form of dengue strikes with devastating seasonal epidemics. The highest morbidity and mortality is in children. This study examined a range of extrinsic factors (climate, land use, demographic, economic) in relation to incidence of severe dengue in Thailand over space and time. Spatial and temporal autocorrelation were high and required iterative adjustments using a general linear model.