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Colloquia Archive
Untitled Document
| DATE: |
Friday, March 28th, 2008 |
| TITLE: |
METHODS FOR RIGID-BODY AND FLEXIBLE FITTING IN 3-D ELECTRON-MICROSCOPY
IMAGES
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| TIME: |
3:30 PM |
| LOCATION: |
GMCS 214 |
| SPEAKER: |
Julio Kovacs
Abagyan Laboratory
The Scripps Research Institute
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| ABSTRACT: |
I will describe methods developed in our lab
to perform the fitting of given atomic structures of protein molecules into
3-D images obtained by electron microscopy. These images, also called maps,
are of limited resolution and thus individual atoms are not visible. Therefore
researchers resort to fitting techniques in an attempt to test hypotheses
regarding the conformation and arrangement of the molecules within the observed
maps. These techniques fall into one of two types: rigid-body or flexible
fitting. I will discuss one technique of each type and show examples of
applications. The rigid-body fitting method is general and so can be applied
in other areas; in contrast, the flexible-fitting one is more specific to
the geometry and degrees of freedom of protein molecules.
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| HOST: |
Antonia Palacios |
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Computational Science Research Center :: 5500 Campanile Drive :: San Diego, CA 92182-1245 :: (619) 594-3430
©2007 Computational Science Research Center, SDSU - All rights
reserved.
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Last
updated:
February 21, 2008 8:38 AM
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